Carbapenem-resistant Acinetobacter baumannii producing OXA-23 in Thailand

Jpn J Infect Dis. 2009 Mar;62(2):152-4.

Abstract

We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The bla(OXA-23) gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo beta-lactamase gene, bla(IMP). The bla(OXA-23) and bla(IMP) genes were plasmid-mediated according to the transformation assays. This is the first description of OXA-23-producing A. baumannii from Thailand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Carbapenems / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial*
  • Genes, Bacterial
  • Hospitals
  • Humans
  • Microbial Sensitivity Tests
  • Plasmids
  • Thailand
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • DNA, Bacterial
  • beta-lactamase OXA-23
  • beta-Lactamases