Abstract
We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The bla(OXA-23) gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo beta-lactamase gene, bla(IMP). The bla(OXA-23) and bla(IMP) genes were plasmid-mediated according to the transformation assays. This is the first description of OXA-23-producing A. baumannii from Thailand.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology*
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Acinetobacter baumannii / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology*
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial*
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Genes, Bacterial
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Hospitals
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Humans
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Microbial Sensitivity Tests
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Plasmids
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Thailand
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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beta-lactamase OXA-23
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beta-Lactamases