Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man

Chem Commun (Camb). 2009 Apr 7:(13):1733-5. doi: 10.1039/b821058f. Epub 2009 Feb 6.

Abstract

Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzymes / chemistry*
  • Nucleoside Diphosphate Sugars / chemical synthesis*
  • Nucleoside Diphosphate Sugars / chemistry

Substances

  • Enzymes
  • Nucleoside Diphosphate Sugars