Hypocarbia as a pathogenic factor in pontosubicular necrosis

Brain Dev. 1991 May;13(3):155-7. doi: 10.1016/s0387-7604(12)80021-0.

Abstract

In neonates pontosubicular necrosis (PSN) is one of the patterns of acute brain injury, the sites of maximum damage being the basis pontis and the subiculum of the hippocampus. A retrospective clinical and pathological study was performed on 16 preterm and 2 term neonates with PSN and compared with 16 age-matched controls. The results indicated that hypocarbia of less than 20 mmHg was one of the important factors in the pathogenesis of PSN.

MeSH terms

  • Birth Weight / physiology
  • Blood Gas Analysis
  • Brain Injuries / pathology*
  • Carbon Dioxide / blood*
  • Gestational Age
  • Humans
  • Hypoxia / complications
  • Hypoxia / pathology*
  • Infant, Newborn
  • Necrosis / pathology
  • Pons / pathology*

Substances

  • Carbon Dioxide