Abstract
In the course of our screening program for novel metabolites from tunicate-derived fungi, novel sesquiterpenoids, named JBIR-27 (1) and -28 (2), together with known sporogen-AO1 and phomenone, were isolated from the culture broth of Penicillium sp. SS080624SCf1. The structures of 1 and 2 were determined to be eremophilane analogs on the basis of extensive NMR and MS analyses. Sporogen-AO1, phomenone and 2 showed cytotoxicity against human cervical carcinoma cell line HeLa at IC(50) values of 8.3, 19 and 92 microM, respectively, whereas 1 was inactive at a concentration of 80 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Culture Media
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DNA, Fungal / biosynthesis
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DNA, Fungal / metabolism
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Fermentation
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HeLa Cells
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Humans
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Mass Spectrometry
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Molecular Conformation
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Penicillium / chemistry*
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Penicillium / metabolism*
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Urochordata / microbiology*
Substances
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Antibiotics, Antineoplastic
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Culture Media
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DNA, Fungal
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JBIR-27
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JBIR-28
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Sesquiterpenes