Oral anticoagulation therapy such as warfarin administration is of benefit for some groups of older adult patients. However, the increased risk for bleeding is of concern when warfarin is used in this population. This article describes interventions of a performance improvement initiative aimed at improving care management of members receiving warfarin therapy in a large managed long-term care program. These interventions significantly improved in terms of care outcomes including increased monitoring of the international normalized ratio (INR), communication with physicians when problems related to warfarin therapy arose, and education of members or caregivers about warfarin therapy.