[Biocompatible antibacterial polymer coatings with ciprofloxacin extended release]

Abstract

A procedure for application of thin composite coats based on polymers (polyurethane or polyethylene) and ciprofloxacin in active gaseous phase generated by electron beam dispersion under vacuum was developed. The coats were shown to be highly dispersed systems whose components preserved the initial molecular structure and had antibacterial activity. The composite coats based on polyurethane were more stable to ciprofloxacin leaching in isotonic sodium chloride solution.