Polypyrrole nanotubes conjugated with human olfactory receptors: high-performance transducers for FET-type bioelectronic noses

Angew Chem Int Ed Engl. 2009;48(15):2755-8. doi: 10.1002/anie.200805171.

Abstract

Get a whiff of this: Human olfactory receptor (hOR)-conjugated polypyrrole (PPy) nanotubes were integrated into the field-effect transistor (FET) sensor platform for the fabrication of high-performance bioelectronic noses (see picture, S = source, D = drain). The device can translate and amplify hOR-odorant interaction into a detectable signal, and it showed highly sensitive and specific responses toward a target odorant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Butyrates / analysis
  • Butyrates / chemistry
  • Electrodes
  • Electronics / instrumentation
  • Electronics / methods
  • Humans
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Nose / chemistry
  • Polymers / chemistry*
  • Pyrroles / chemistry*
  • Receptors, Odorant / chemistry*
  • Receptors, Odorant / metabolism
  • Transistors, Electronic

Substances

  • Butyrates
  • OR2AG1 protein, human
  • Polymers
  • Pyrroles
  • Receptors, Odorant
  • polypyrrole
  • n-amyl butyrate