Abstract
Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line
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Ecdysone / isolation & purification*
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Ecdysone / pharmacology
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Helleborus / chemistry*
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Molecular Structure
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Plant Extracts / chemistry
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Rats
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Saponins / isolation & purification*
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Saponins / pharmacology
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Sterols / isolation & purification*
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Sterols / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Saponins
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Sterols
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Ecdysone