Bactericidal activity of the combination of levofloxacin with rifampin in experimental prosthetic knee infection in rabbits due to methicillin-susceptible Staphylococcus aureus

Antimicrob Agents Chemother. 2009 May;53(5):2145-8. doi: 10.1128/AAC.01163-08. Epub 2009 Mar 9.

Abstract

The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Humans
  • Knee Prosthesis / microbiology*
  • Levofloxacin*
  • Methicillin* / pharmacology
  • Microbial Sensitivity Tests
  • Ofloxacin* / pharmacology
  • Ofloxacin* / therapeutic use
  • Prosthesis-Related Infections / drug therapy*
  • Prosthesis-Related Infections / microbiology
  • Rabbits
  • Rifampin* / pharmacology
  • Rifampin* / therapeutic use
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Levofloxacin
  • Ofloxacin
  • Methicillin
  • Rifampin