Objective: To analyze the contents of thirty elements and their rule of variation in the samples of women with lung cancer and control population.
Methods: 95 plasma samples of women with lung cancer and 93 plasma samples of control group were collected from Xuanwei and Fuyuan, Yunnan Province where the lung cancer rates are among the highest in China. The samples were determined by inductively coupled plasma mass spectrometry after microwave digestion. SAS 9.0 software was used to analyze the data obtained from the test. T-test was used to measure the statistical differences between the lung cancer group and the control.
Results: The contents of Mn, Ni, Cu, Cd, Sb, Ta and Pb in the plasma samples of lung cancer were higher than those in the control samples (P < 0.05). While the contents of Zn, Se, Rb, Sn, Cs and W in the lung cancer plasma samples were lower than those in the controls (P < 0.05). And the other elements did not have statistital, difference between the two groups.
Conclusion: Significant differences of the concentrations of 13 elements such as Mn, Ni, Cu, Zn, Se, Rb, Cd, Sn, Sb, Cs, Ta, W and Pb were found between the plasma samples of lung cancer group and the control group, which indicated that the contents of elements were related to the generation and development of lung cancer.