Abstract
Clostridial neurotoxins possess discrete structural domains with distinct pharmacological properties. Aspects of neurotoxin function with therapeutic potential include specific neuronal binding, intracellular (cytosolic) delivery of biologically active protein and inhibition of SNARE-mediated secretion. Understanding the structure function relationship of the neurotoxin protein enables the creation of recombinant proteins incorporating select domains of the neurotoxins to produce novel proteins with therapeutic potential in a range of clinical applications.
MeSH terms
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Animals
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Botulinum Toxins / chemical synthesis
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Botulinum Toxins / chemistry*
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Botulinum Toxins / pharmacology
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Drug Design*
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Humans
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Neurotoxins / chemical synthesis
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Neurotoxins / chemistry*
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Neurotoxins / pharmacology
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Protein Conformation
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Protein Engineering*
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Recombinant Proteins / chemical synthesis
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Recombinant Proteins / chemistry
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Recombinant Proteins / pharmacology
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Structure-Activity Relationship
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Tetanus Toxin / chemical synthesis
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Tetanus Toxin / chemistry*
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Tetanus Toxin / pharmacology
Substances
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Neurotoxins
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Recombinant Proteins
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Tetanus Toxin
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Botulinum Toxins