Abstract
It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Biosensing Techniques / methods
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Cell Line
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Diagnostic Imaging
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Fluorescence Resonance Energy Transfer*
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Fluorescent Dyes / chemistry
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Mice
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Nanoparticles / chemistry*
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Oxygen / analysis*
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Oxygen / chemistry
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Platinum / chemistry
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Polymers / chemistry
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Porphyrins / chemistry
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Spectrophotometry, Ultraviolet
Substances
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Fluorescent Dyes
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Polymers
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Porphyrins
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Platinum
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Oxygen