Effect of HIF1A gene polymorphism on human muscle performance

I I Ahmetov; A M Hakimullina; E V Lyubaeva; O L Vinogradova; V A Rogozkin

doi:10.1007/s10517-008-0291-3

Effect of HIF1A gene polymorphism on human muscle performance

Bull Exp Biol Med. 2008 Sep;146(3):351-3. doi: 10.1007/s10517-008-0291-3.

Authors

I I Ahmetov¹, A M Hakimullina, E V Lyubaeva, O L Vinogradova, V A Rogozkin

Affiliation

¹ St. Petersburg Institute of Physical Culture, Moscow, Russia.

PMID: 19240858
DOI: 10.1007/s10517-008-0291-3

Abstract

Allele distribution of hypoxia-inducible factor gene (HIF1A; Pro582Ser polymorphism) was studied in power-oriented athletes and controls practicing no athletics; genotype relationships with muscle fiber composition were studied in speed skaters. Genotyping was carried out by PCR. The composition of muscle fibers was evaluated by the immunohistochemical analysis of m. vastus lateralis. The incidence of HIF1A Ser allele was significantly higher in weight-lifters than in controls (17.9 vs. 8.5%; p=0.001) and increased with athletic skill improvement. A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007). Hence, HIF1A Pro582Ser polymorphism is associated with muscle activity in humans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Exercise
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
Hypoxia-Inducible Factor 1, alpha Subunit / physiology
Male
Muscle Contraction / physiology*
Muscle Fibers, Fast-Twitch / physiology*
Muscle, Skeletal / physiology*
Polymorphism, Genetic
Sports
Young Adult

Substances

HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit