Studying the pathogenicity of avian influenza virus subtype H5N1 strains from the Russian Federation using mouse model

A M Shestopalov; K A Sharshov; A V Zaykovskaya; Yu N Rassadkin; I G Drozdov; V A Shkurupy; O V Potapova; N G Luzgina

doi:10.1007/s10517-008-0296-y

Studying the pathogenicity of avian influenza virus subtype H5N1 strains from the Russian Federation using mouse model

Bull Exp Biol Med. 2008 Sep;146(3):341-3. doi: 10.1007/s10517-008-0296-y.

Authors

A M Shestopalov¹, K A Sharshov, A V Zaykovskaya, Yu N Rassadkin, I G Drozdov, V A Shkurupy, O V Potapova, N G Luzgina

Affiliation

¹ State Research Center of Virology and Biotechnology "Vector", Federal Service on Surveillance for Consumer Rights Protection and Human Well-being, Novosibirsk region, Kol'tsovo, Novosibirsk oblast, Russia. shestopalov@mail.ru

PMID: 19240855
DOI: 10.1007/s10517-008-0296-y

Abstract

The pathogenicity of strains of avian influenza virus subtype H5N1 from the Russian Federation (A/turkey/Suzdalka/12/05, A/goose/Krasnoozerskoye/627/05, A/duck/Tuva/01/06, A/chicken/Reshoty/02/06, and A/chicken/Krasnodar/123/060) was studied in mice. Morphological and immunological characteristics of experimental viral infection with avian influenza virus subtype H5N1 were evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / virology
Cytokines / metabolism
Influenza A Virus, H5N1 Subtype / growth & development
Influenza A Virus, H5N1 Subtype / pathogenicity*
Kidney / virology
Liver / virology
Lung / virology
Mice
Orthomyxoviridae Infections / mortality
Spleen / virology

Substances

Cytokines