Abstract
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemical synthesis*
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / pharmacology*
-
Anti-Inflammatory Agents / therapeutic use
-
Antioxidants / chemical synthesis*
-
Antioxidants / chemistry
-
Antioxidants / pharmacology*
-
Antioxidants / therapeutic use
-
Coumarins / chemistry*
-
Edema / chemically induced
-
Edema / drug therapy
-
Female
-
Glycine max / enzymology
-
Lipoxygenase / metabolism
-
Lipoxygenase Inhibitors / chemical synthesis
-
Lipoxygenase Inhibitors / chemistry
-
Lipoxygenase Inhibitors / pharmacology
-
Lipoxygenase Inhibitors / therapeutic use
-
Male
-
Rats
-
Thioctic Acid / chemistry*
Substances
-
Anti-Inflammatory Agents
-
Antioxidants
-
Coumarins
-
Lipoxygenase Inhibitors
-
Thioctic Acid
-
coumarin
-
Lipoxygenase