General chromatographic NMR method in liquid state for synthetic chemistry: polyvinylpyrrolidone assisted DOSY experiments

Jari S Kavakka; Ilkka Kilpeläinen; Sami Heikkinen

doi:10.1021/ol9001398

General chromatographic NMR method in liquid state for synthetic chemistry: polyvinylpyrrolidone assisted DOSY experiments

Org Lett. 2009 Mar 19;11(6):1349-52. doi: 10.1021/ol9001398.

Authors

Jari S Kavakka¹, Ilkka Kilpeläinen, Sami Heikkinen

Affiliation

¹ Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014, University of Helsinki, Finland.

PMID: 19231850
DOI: 10.1021/ol9001398

Abstract

A polymer assisted liquid state DOSY NMR technique, to extract the spectra of the individual components from mixtures in CDCl(3), is demonstrated. The enhancement of diffusion coefficient differences is achieved using a soluble polymer, polyvinylpyrrolidone, as the "stationary phase". The "separation" of analytes resembles normal-phase chromatography, for example, TLC. This method provides a fast, cheap, and simple technique to resolve the NMR spectra of complex mixtures.