Abstract
The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor-ligand pairs that are endowed with costimulatory properties and their importance in health and disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Humans
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Immunity, Cellular / immunology*
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Killer Cells, Natural / immunology
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Killer Cells, Natural / metabolism
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Ligands
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Macrophages / immunology
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Macrophages / metabolism
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Protein Kinases / immunology
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Protein Kinases / metabolism
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Signal Transduction / immunology
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Signal Transduction / physiology
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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Tumor Necrosis Factors / immunology*
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Tumor Necrosis Factors / metabolism
Substances
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Ligands
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Tumor Necrosis Factors
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Protein Kinases