Chronotropic response to exercise after pulmonary veins isolation or Cox-maze operation

Rev Bras Cir Cardiovasc. 2008 Oct-Dec;23(4):474-9. doi: 10.1590/s0102-76382008000400004.
[Article in English, Portuguese]

Abstract

Objective: To evaluate the chronotropic response to exercise during immediate and late postoperative period after atrial fibrillation and mitral valve surgical treatment by different techniques.

Methods: Prospective controlled clinical study of 42 patients presenting chronic AF associated mitral valve disease, who underwent surgery by the techniques of pulmonary veins isolation (n=16), Modified Cox-maze procedure, without cryoablation (n=13), both with isolated mitral valve repair (n=13). The preoperative clinical characteristics, surgical indications, kind and aetiology of valve lesion were similar between groups. The patients were outpatient followed-up and underwent series of ergometric tests.

Results: In the immediate postoperative period, chronotropic response was similar in the 3 groups with mean of 73.6 +/- 12.3% of maximal calculated heart rate. In the surgical pulmonary veins isolation group, there was an increment of heart rate, from 64.4 +/- 12.4% of maximal heart rate in the immediate postoperative period to 78.9 +/- 10.5% in the 12th month (P=0.012) of postoperative. In the Cox-maze group, heart rate varied, respectively, from 73.9 +/- 11.14% to 78.8 +/- 15.2% (P=1.000) and in the control group (only mitral valve surgery), from 67.2 +/- 14.3% to 71.9 +/- 12.9% (P=0.889).

Conclusion: An attenuation of immediate postoperative chronotropic response to exercise was similar in the postoperative in the three different surgical techniques. There was a significant improvement in this response concerning to postoperative outcome in the pulmonary veins isolation group. These results suggest that simple surgical pulmonary veins isolation may be related to a better preservation of atrial chronotropism.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Atrial Fibrillation / surgery*
  • Cardiac Surgical Procedures / methods
  • Catheter Ablation / methods
  • Exercise / physiology*
  • Exercise Test
  • Female
  • Heart Atria / pathology
  • Heart Rate / physiology*
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve Insufficiency / surgery*
  • Postoperative Period
  • Prospective Studies
  • Pulmonary Veins / surgery*
  • Young Adult