Total synthesis of (-)-amphidinolide K

Angew Chem Int Ed Engl. 2009;48(13):2364-6. doi: 10.1002/anie.200805266.

Abstract

Macrolide magic: An enyne cross-metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic beta-alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (-)-amphidinolide K.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Cyclization
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Stereoisomerism

Substances

  • Alkenes
  • Macrolides
  • amphidinolide K