Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT

Veronica Esposito; Antonella Virgilio; Antonietta Pepe; Giorgia Oliviero; Luciano Mayol; Aldo Galeone

doi:10.1016/j.bmc.2009.01.027

Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT

Bioorg Med Chem. 2009 Mar 1;17(5):1997-2001. doi: 10.1016/j.bmc.2009.01.027. Epub 2009 Jan 20.

Authors

Veronica Esposito¹, Antonella Virgilio, Antonietta Pepe, Giorgia Oliviero, Luciano Mayol, Aldo Galeone

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali,Università degli Studi di Napoli Federico II, Napoli, Italy.

PMID: 19217303
DOI: 10.1016/j.bmc.2009.01.027

Abstract

Insight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Circular Dichroism
G-Quadruplexes*
Glycosides / chemistry*
Magnetic Resonance Spectroscopy
Nucleic Acid Conformation
Oligodeoxyribonucleotides / chemistry*
Transition Temperature

Substances

Glycosides
Oligodeoxyribonucleotides