Inhibition of selectin binding by colloidal gold with functionalized shells

Chem Commun (Camb). 2009 Feb 28:(8):932-4. doi: 10.1039/b818263a. Epub 2009 Jan 15.

Abstract

Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC(50) values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Contact Inhibition
  • Electrophoresis, Agar Gel
  • Gold Colloid / chemistry*
  • Gold Colloid / metabolism
  • Inhibitory Concentration 50
  • L-Selectin / metabolism*
  • Leukocytes / metabolism
  • Ligands
  • P-Selectin / metabolism*

Substances

  • Gold Colloid
  • Ligands
  • P-Selectin
  • L-Selectin