Antiviral defense: RIG-Ing the immune system to STING

Cytokine Growth Factor Rev. 2009 Feb;20(1):1-5. doi: 10.1016/j.cytogfr.2009.01.001. Epub 2009 Feb 10.

Abstract

A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism
  • Cytosol / metabolism
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / metabolism
  • DEAD-box RNA Helicases / physiology*
  • Humans
  • Immune System
  • Interferon Type I / metabolism
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Protein Binding
  • Protein Conformation
  • RNA, Viral / metabolism
  • Receptors, Immunologic
  • Signal Transduction
  • Transcription, Genetic

Substances

  • Interferon Type I
  • Membrane Proteins
  • RNA, Viral
  • Receptors, Immunologic
  • STING1 protein, human
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases