Total of 73 patients with chronic generalized periodontitis at the age from 20 to 62 years have been studied. In 38 patients severe form of pathology was observed, while in 35--an average form. At admission to hospital both general and local immunity disorders were observed in patients; changes in immunological indices progressed with the deterioration of pathology. The combined treatment with the use of zinc electrophoresis and millimetre range waves of electromagnetic field in patients with chronic periodontitis induced the increase of the quantity of T-lymphocytes and their helper substances in peripheral blood, phagocytal number, phagocytal index and the index of digestion of microbes by neutrophils, the content of interleukin-4 in blood serum and saliva. It also induced the increase of the content of secretory immunoglobulin A in saliva. The content of B-lymphocytes in peripheral blood, immunoglobulin of A and G classes, interleukin-12 and -interferon in blood serum and saliva underwent reverse changes. The decrease of immunoglobulin of class M in blood serum was also noted. The trace concentrations of immunoglobulin of M class were revealed in saliva both before and after the treatment. The above mentioned positive process induced in patients with chronic generalized periodontitis by means of combined treatment using zinc electrophoresis and millimetre range waves of electromagnetic field was more expressed at benign form of the pathology.