Abstract
The standard administration of the investigational Japanese encephalitis vaccine IC51 is 2 doses of 6 microg with a 28-day interval. This study investigated the immunogenicity of a single-immunization, high-dose regimen (1 x 12 microg) compared to the 2-injection, standard regimen to determine the immune response that one, high-dose injection can confer. The single, high-dose regimen resulted in about 60% seroconversion rate (SCR) at 10 days after administration, but it did not reach the almost 100% SCR achieved by the 2-dose standard administration at Day 35. The standard regimen conferred essentially 100% seroconversion already 7 days after the second immunization.
Publication types
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Clinical Trial, Phase III
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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Encephalitis Virus, Japanese / immunology
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Encephalitis, Japanese / prevention & control*
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Female
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Humans
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Immunization, Secondary
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Japanese Encephalitis Vaccines / administration & dosage*
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Japanese Encephalitis Vaccines / adverse effects
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Japanese Encephalitis Vaccines / immunology
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Male
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Middle Aged
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Single-Blind Method
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Vaccination / methods*
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / adverse effects
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Vaccines, Inactivated / immunology
Substances
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Antibodies, Viral
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Japanese Encephalitis Vaccines
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Vaccines, Inactivated