In this work we introduce an efficient method for averting non-specific adsorption of various nanoparticles to typical oxide surfaces, such as glass, quartz, and sapphire, through the attachment of a fluorinated self-assembled monolayer (SAM) that minimizes the interactions between stabilized nanoparticles and these surfaces. This surface treatment is shown to be effective for a variety of nanoparticles in a range of solvent systems. As a result, monitoring and characterization of nanoparticles and their surface chemistry is allowed, while simultaneously preventing loss of expensive nanomaterials to the various surfaces inherent in laboratory apparatus.