Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression

C Andrew Stewart; Giorgio Trinchieri

doi:10.1016/j.ccr.2009.01.008

Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression

Cancer Cell. 2009 Feb 3;15(2):81-3. doi: 10.1016/j.ccr.2009.01.008.

Authors

C Andrew Stewart¹, Giorgio Trinchieri

Affiliation

¹ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.

PMID: 19185840
DOI: 10.1016/j.ccr.2009.01.008

Abstract

STAT3 plays many roles in tumorigenesis. In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells. STAT3 also mediates IL-23's effect of activating tumor-infiltrating regulatory T cells.

Publication types

Comment

MeSH terms

Animals
Immunosuppression Therapy*
Interleukin-12 / immunology
Interleukin-23 / immunology*
Lymphocyte Activation / immunology
Neoplasms / immunology*
STAT3 Transcription Factor / immunology*
T-Lymphocytes, Regulatory / immunology*

Substances

Interleukin-23
STAT3 Transcription Factor
Interleukin-12