How to synchronize biological clocks

J Comput Biol. 2009 Feb;16(2):379-93. doi: 10.1089/cmb.2008.21TT.

Abstract

This paper is concerned with a novel algorithm to study networks of biological clocks. A new set of conditions is established that can be used to verify whether an existing network synchronizes or to give guidelines to construct a new synthetic network of biological oscillators that synchronize. The methodology uses the so-called contraction theory from dynamical system theory and Gershgorin disk theorem. The strategy is validated on two examples: a model of glycolisis in yeast cells and a synthetic network of Repressilators that synchronizes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Biological Clocks / physiology*
  • Circadian Rhythm / physiology*
  • Computer Simulation*
  • Mathematics
  • Models, Biological*
  • Neural Networks, Computer
  • Yeasts / physiology