Abstract
Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome of Campylobacter jejuni NCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins / genetics*
-
Bacterial Proteins / metabolism
-
Biosynthetic Pathways
-
Campylobacter jejuni / chemistry
-
Campylobacter jejuni / genetics*
-
Campylobacter jejuni / growth & development
-
Campylobacter jejuni / metabolism
-
Gene Deletion*
-
Lipopolysaccharides / biosynthesis*
-
Lipopolysaccharides / chemistry
-
Microbial Viability*
-
Multigene Family*
-
Mutation
Substances
-
Bacterial Proteins
-
Lipopolysaccharides
-
lipid-linked oligosaccharides