Abstract
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Ciprofloxacin / chemical synthesis*
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Ciprofloxacin / pharmacology
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Citric Acid / chemical synthesis*
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Citric Acid / pharmacology
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Escherichia coli K12 / drug effects
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Escherichia coli K12 / genetics
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Escherichia coli K12 / growth & development
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Gene Deletion
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Humans
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Porins / deficiency
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Porins / genetics
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / growth & development
Substances
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OmpF protein
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Porins
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Citric Acid
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Ciprofloxacin