Abstract
The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl(2) catalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Azithromycin / chemical synthesis*
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Azithromycin / chemistry
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Catalysis
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Copper / chemistry
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Erythromycin / chemistry
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Imines / chemistry
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Stereoisomerism
Substances
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Anti-Bacterial Agents
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Imines
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Erythromycin
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Copper
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Azithromycin