Preventive measures in infancy to reduce under-five mortality: a case-control study in The Gambia

Trop Med Int Health. 2009 Feb;14(2):149-55. doi: 10.1111/j.1365-3156.2008.02204.x. Epub 2009 Jan 20.

Abstract

Objective: To investigate the relationship between child mortality and common preventive interventions: vaccination, trained birthing attendants, tetanus toxoid during pregnancy, breastfeeding and vitamin A supplementation.

Methods: Case-control study in a population under demographic surveillance. Cases (n = 141) were children under five who died. Each was age and sex-matched to five controls (n = 705). Information was gathered by interviewing primary caregivers.

Results: All but one of the interventions - whether the mother had received tetanus toxoid during pregnancy - were protective against child mortality after multivariate analysis. Having a trained person assisting at child birth (OR 0.2 95% CI 0.1-0.4), receiving all vaccinations by 9 months of age (OR 0.1; 95% CI 0.01-0.3), being breastfed for more than 12 months (Children breastfed between 13 and 24 months OR 0.1 95% CI 0.03-0.3, more than 25 months OR 0.1 95% CI 0.01-0.5) and receiving vitamin A supplementation at or after 6 months of age (OR 0.05; 95% CI 0.01-0.2) were protective against child death.

Conclusions: This study confirms the value of at least four available interventions in the prevention of under-five death in The Gambia. It is now important to identify those who are not receiving them and why, and to intervene to improve coverage across the population.

MeSH terms

  • Breast Feeding / statistics & numerical data
  • Caregivers
  • Case-Control Studies
  • Child Mortality*
  • Child, Preschool
  • Female
  • Gambia / epidemiology
  • Humans
  • Infant
  • Infant Mortality*
  • Infant, Newborn
  • Male
  • Midwifery / methods
  • Multivariate Analysis
  • Pregnancy
  • Preventive Health Services / methods*
  • Tetanus Toxoid / therapeutic use
  • Vaccination
  • Vitamin A / therapeutic use

Substances

  • Tetanus Toxoid
  • Vitamin A