Abstract
A new quinoline antibiotic, aurachin RE, was isolated and identified from a culture broth of Rhodococcus erythropolis JCM 6824. The aurachin RE structure was determined based on NMR and mass spectrometric analysis. The structure is similar to that of aurachin C antibiotics that have been identified from Stigmatella aurantiaca. Compared to aurachin C, however, aurachin RE exhibits a wide and strong antimicrobial spectrum against both high- and low-GC Gram-positive bacteria.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Culture Media / chemistry*
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Gram-Positive Bacteria / drug effects
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Hydroxylamines / chemistry
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Hydroxylamines / isolation & purification*
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Hydroxylamines / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Molecular Structure
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Quinolones / chemistry
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Quinolones / isolation & purification*
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Quinolones / pharmacology*
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Rhodococcus / growth & development
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Rhodococcus / metabolism*
Substances
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Anti-Bacterial Agents
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Culture Media
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Hydroxylamines
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Quinolones
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aurachin RE