A quinoline antibiotic from Rhodococcus erythropolis JCM 6824

J Antibiot (Tokyo). 2008 Nov;61(11):680-2. doi: 10.1038/ja.2008.96.

Abstract

A new quinoline antibiotic, aurachin RE, was isolated and identified from a culture broth of Rhodococcus erythropolis JCM 6824. The aurachin RE structure was determined based on NMR and mass spectrometric analysis. The structure is similar to that of aurachin C antibiotics that have been identified from Stigmatella aurantiaca. Compared to aurachin C, however, aurachin RE exhibits a wide and strong antimicrobial spectrum against both high- and low-GC Gram-positive bacteria.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Culture Media / chemistry*
  • Gram-Positive Bacteria / drug effects
  • Hydroxylamines / chemistry
  • Hydroxylamines / isolation & purification*
  • Hydroxylamines / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Quinolones / chemistry
  • Quinolones / isolation & purification*
  • Quinolones / pharmacology*
  • Rhodococcus / growth & development
  • Rhodococcus / metabolism*

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Hydroxylamines
  • Quinolones
  • aurachin RE