Objective: To describe a bigeminal pregnancy obtained with a homologous intracytoplasmic sperm injection cycle in a patient with high-grade mosaic Turner syndrome (45,XO/47,XXX 97.5%/2.5%) with bicuspid aortic valve.
Design: Case report.
Setting: Unit of Pathophysiology of Human Reproduction in a general hospital.
Patient(s): Patient with mosaic Turner syndrome with bicuspid aortic valve.
Intervention(s): Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.
Main outcome measure(s): Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.
Result(s): Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.
Conclusion(s): Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.