Interactions of a tetraanionic porphyrin with DNA: from a Z-DNA sensor to a versatile supramolecular device

J Am Chem Soc. 2009 Feb 18;131(6):2046-7. doi: 10.1021/ja808099u.

Abstract

The anionic nickel(II) porphyrin NiTPPS is able to selectively sense the spermine induced left-handed Z-form of DNA while it is completely silent in the presence of right-handed B-DNA. Interactions between the DNA and the porphyrin can be easily modulated by pH and temperature. The resulting Z-DNA-porphyrin-spermine complex behaves as a supramolecular reversible information storage system and as a reversible AND logic gate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Circular Dichroism
  • DNA, Z-Form / chemistry*
  • Hydrogen-Ion Concentration
  • Macromolecular Substances / chemistry
  • Metalloporphyrins / chemistry*
  • Models, Molecular
  • Nickel / chemistry
  • Nucleic Acid Conformation
  • Polydeoxyribonucleotides / chemistry
  • Porphyrins / chemistry
  • Spermine / chemistry
  • Stereoisomerism

Substances

  • DNA, Z-Form
  • Macromolecular Substances
  • Metalloporphyrins
  • Polydeoxyribonucleotides
  • Porphyrins
  • poly(dC-dG)
  • Spermine
  • tetraphenylporphine sulfonate
  • Nickel