An efficient and chemoselective synthesis of benzo[e][1,4]thiazepin-2(1H,3H,5H)-ones via a microwave-assisted multi-component reaction in water

Org Biomol Chem. 2009 Feb 7;7(3):557-63. doi: 10.1039/b815879g. Epub 2009 Jan 5.

Abstract

A new and efficient strategy for the synthesis of benzo[e][1,4]thiazepin-2(1H,3H,5H)-ones via a microwave-assisted multi-component reaction in aqueous media is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Aniline Compounds / chemistry
  • Green Chemistry Technology
  • Microwaves*
  • Substrate Specificity
  • Temperature
  • Thiazepines / chemical synthesis*
  • Thiazepines / chemistry
  • Thiazolidines / chemistry
  • Thioglycolates / chemistry
  • Water / chemistry*

Substances

  • Aldehydes
  • Aniline Compounds
  • Thiazepines
  • Thiazolidines
  • Thioglycolates
  • Water
  • 2-mercaptoacetate
  • aniline