The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat

Craig S McLachlan; Justin M Farook; Valérie Daugé; Peter T Wong

doi:10.1016/j.peptides.2008.12.013

The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat

Peptides. 2009 Apr;30(4):808-9. doi: 10.1016/j.peptides.2008.12.013. Epub 2008 Dec 25.

Authors

Craig S McLachlan¹, Justin M Farook, Valérie Daugé, Peter T Wong

Affiliation

¹ Department of Pharmacology, National University of Singapore, Singapore. reperfusion@hotmail.com

PMID: 19150473
DOI: 10.1016/j.peptides.2008.12.013

Abstract

BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).

MeSH terms

Animals
Cats
Cholecystokinin / analogs & derivatives*
Cholecystokinin / pharmacology
Dose-Response Relationship, Drug
Fear*
Peptide Fragments / pharmacology*
Predatory Behavior*
Rats
Receptor, Cholecystokinin B / agonists*

Substances

BC 264
Peptide Fragments
Receptor, Cholecystokinin B
Cholecystokinin