Abstract
In experiments on Wistar rats L-lysine (0.15, 0.5, 1.5, 5.0, 15.0, and 50.0 microg/kg intraperitoneally) exhibited a dose-dependent algic effect during electrocutaneous stimulation of the tail and dose-dependent effects in aggressive defense behavior caused by electrical painful stimulation of paws. It was found that the effect of L-lysine depended on situation determining the predominance of defense or aggression, rather than on the intensity of painful stimulation.
MeSH terms
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Aggression / drug effects
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Animals
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Behavior, Animal / drug effects*
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Behavior, Animal / physiology
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Central Nervous System Agents / administration & dosage
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Central Nervous System Agents / pharmacology
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Dose-Response Relationship, Drug
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Electroshock
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Lysine / administration & dosage
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Lysine / pharmacology*
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Male
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Neurotransmitter Agents / physiology
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Pain / physiopathology
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Pain / psychology*
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Pain Threshold / drug effects
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Pain Threshold / psychology
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Rats
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Rats, Wistar
Substances
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Central Nervous System Agents
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Neurotransmitter Agents
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Lysine