The growth in Asian immigration and a diversity of Asian populations living in Western English-speaking societies pose many opportunities for qualitative research. Cultural competence is essential to credible qualitative nursing research employing interview data. The purpose of this article is to describe culturally competent qualitative research with Asian immigrants, especially in the design, interview phases, and analysis. Strategies to achieve cultural competence are synthesized within the model of cultural competence, integrating the literature review and data exemplars. Strategies for successful conduct of qualitative research in Asian immigrant populations, including preparation of the research team, techniques for the conduct of research interviews with Asian immigrants, and contextual meanings and timing of translation are offered. The article concludes with a summary of implications for future research.