Our search for biologically active marine natural products led to the isolation of two new ceramides, iotrochotamide I and iotrochotamide II, together with three known 6-bromoindole alkaloids (6-bromo-1H-indole-3-carbaldehyde, 6-bromo-1H-indole-3-carboxylic acid methyl ester, and 6-bromo-1H-indole-3-carboxylic acid ethyl ester) from the sponge Iotrochota purpurea collected in Indonesia. The structure elucidation of these compounds was secured by spectroscopic methods (1H, 13C, DEPT, COSY, HMQC and HMBC), accurate mass measurements (ESI, EI and GS-MS) as well as comparison with known compounds.