Abstract
Evidence for the possible involvement of the mitochondrial cyclosporin A-insensitive palmitate/Ca(2+)-activated pore in the apoptotic process is presented. It has been established that the opening of palmitate/Ca(2+)-activated pore results in high-amplitude swelling of mitochondria and the release of apoptosis-induced factor from organelles. These processes are accompanied by a transitory small decrease of membrane potential, which recovers in 1 min. The possible role of palmitate/Ca(2+)-activated pore in the induction of palmitate-activated apoptosis is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis Inducing Factor / metabolism
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Apoptosis*
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Calcium / physiology*
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Culture Media
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In Vitro Techniques
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Membrane Potential, Mitochondrial
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Mitochondria, Liver / physiology*
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Mitochondrial Membrane Transport Proteins / physiology
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Mitochondrial Permeability Transition Pore
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Mitochondrial Proteins / physiology*
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Palmitic Acid / metabolism*
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Palmitic Acid / pharmacology
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Phosphates / pharmacology
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Rats
Substances
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Apoptosis Inducing Factor
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Culture Media
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Mitochondrial Membrane Transport Proteins
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Mitochondrial Permeability Transition Pore
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Mitochondrial Proteins
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Phosphates
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Palmitic Acid
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Calcium