Abstract
Five new compounds, ailanthamide (1), N-(4-methoxyphenethyl)-N-methylbenzamide (2), (2E,4E)-N-isobutyl-6-oxohepta-2,4-dienamide (3), 4-(4'-hydroxy-3'-methylbutoxy)benzaldehyde (4), and (E)-methyl 4-[4-(3-hydroxypropyl)phenoxy]-2-methylbut-2-enoate (5), and 17 known compounds have been isolated from the stem bark of Zanthoxylum ailanthoides. The structures were determined through spectroscopic and MS analyses. Compounds 1, 3, xanthyletin, decarine, (+)-episesamin, (-)-hinokinin, and evofolin-B exhibited inhibition (IC(50) < or = 5.34 microg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, xanthyletin, decarine, and (+)-episesamin also inhibited fMLP/CB-induced elastase release with IC(50) values < or = 5.53 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / pharmacology
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Amides / chemistry
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Amides / isolation & purification*
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Amides / pharmacology*
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Benzamides / chemistry
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Benzamides / isolation & purification*
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Benzamides / pharmacology*
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Benzene Derivatives / chemistry
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Benzene Derivatives / isolation & purification*
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Benzene Derivatives / pharmacology*
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Benzodioxoles
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Coumarins / pharmacology
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Dioxoles / pharmacology
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Humans
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Inhibitory Concentration 50
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Lignans / pharmacology
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Molecular Structure
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Pancreatic Elastase / antagonists & inhibitors*
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Pancreatic Elastase / metabolism
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Superoxides / antagonists & inhibitors*
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Taiwan
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Zanthoxylum / chemistry*
Substances
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Amides
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Benzamides
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Benzene Derivatives
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Benzodioxoles
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Coumarins
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Dioxoles
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Lignans
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Superoxides
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hinokinin
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xanthyletine
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Pancreatic Elastase
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4-Butyrolactone
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sesamin