Intrathecal methotrexate-induced acute chorea

J Pediatr Hematol Oncol. 2009 Jan;31(1):57-8. doi: 10.1097/MPH.0b013e318190d434.

Abstract

Intrathecal methotrexate is the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia. We describe a patient who developed acute chorea after last dose of intrathecal methotrexate therapy and recovered completely.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Child
  • Chorea / chemically induced*
  • Chorea / drug therapy
  • Female
  • Humans
  • Injections, Spinal
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Treatment Outcome

Substances

  • Antimetabolites, Antineoplastic
  • Methotrexate