Abstract
Antibiotic susceptibilities of Propionibacterium acnes in Japan were determined. Erythromycin-resistance was found in 10.4% (5/48) of the strains, and four of these were cross-resistance to clindamycin. Although the erythromycin ribosome methylase gene erm(X) was looked for, no strain carrying erm(X) was found. Sequencing analysis revealed that all of the erythromycin-resistant strains had a mutation in the peptidyl transferase region of the 23S rRNA gene: G2057A, A2058G, or A2059G. Consequently, our results show that P. acnes resistance to macrolides is caused by a mutation in the 23S rRNA gene, and has been increasing in Japan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acne Vulgaris / microbiology*
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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DNA, Bacterial / genetics
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DNA, Ribosomal / genetics
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Drug Resistance, Bacterial*
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Gram-Positive Bacterial Infections / microbiology*
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Humans
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Japan
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Microbial Sensitivity Tests
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Mutation
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Peptidyl Transferases / genetics
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Peptidyl Transferases / metabolism
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Propionibacterium acnes / drug effects*
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Propionibacterium acnes / genetics
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Propionibacterium acnes / isolation & purification*
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Propionibacterium acnes / metabolism
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RNA, Ribosomal, 23S / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 23S
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Peptidyl Transferases