Effects of cytotoxins on intracellular na/K balance in mouse embryonic cell

Bull Exp Biol Med. 2008 Apr;145(4):531-4. doi: 10.1007/s10517-008-0134-2.

Abstract

Cytoplasmic Na/K imbalance induced by cytotoxic substances (ethylene glycol and cytochalasin B) was studied. Incubation in Dulbecco's medium with these cytotoxins caused changes in K and Na concentrations in the mouse two-cell embryo blastomer. The effects of both substances resulted in a drop of Na content in the embryonic cell. Washing from cytochalasin B restored the initial Na/K balance in the cytoplasm. Possible adaptive mechanisms involved in the regulation of intracellular ionic homeostasis are discussed.

MeSH terms

  • Algorithms
  • Animals
  • Cytochalasin B / pharmacology
  • Cytotoxins / pharmacology*
  • Embryo, Mammalian
  • Embryonic Development / drug effects
  • Embryonic Stem Cells / drug effects*
  • Embryonic Stem Cells / metabolism
  • Ethylene Glycol / pharmacology
  • Homeostasis / drug effects*
  • Intracellular Fluid / chemistry*
  • Intracellular Fluid / drug effects
  • Intracellular Fluid / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Potassium / analysis*
  • Potassium / metabolism
  • Sodium / analysis*
  • Sodium / metabolism

Substances

  • Cytotoxins
  • Cytochalasin B
  • Sodium
  • Ethylene Glycol
  • Potassium