Mitofusin 2 builds a bridge between ER and mitochondria

Carsten Merkwirth; Thomas Langer

doi:10.1016/j.cell.2008.12.005

Mitofusin 2 builds a bridge between ER and mitochondria

Cell. 2008 Dec 26;135(7):1165-7. doi: 10.1016/j.cell.2008.12.005.

Authors

Carsten Merkwirth¹, Thomas Langer

Affiliation

¹ Institute for Genetics, Centre for Molecular Medicine (CMMC), University of Cologne, 50674 Cologne, Germany.

PMID: 19109886
DOI: 10.1016/j.cell.2008.12.005

Abstract

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Axonal Transport
Cell Line
Endoplasmic Reticulum / metabolism*
GTP Phosphohydrolases / metabolism*
Mice
Mitochondria / metabolism*
Purkinje Cells / metabolism

Substances

GTP Phosphohydrolases
Mfn1 protein, mouse
Mfn2 protein, mouse