Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features

Pediatr Infect Dis J. 2009 Feb;28(2):161-3. doi: 10.1097/INF.0b013e318185513d.

Abstract

An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRalphabeta, CD4, CD8 cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Allopurinol / therapeutic use
  • Amphotericin B / therapeutic use
  • Antipruritics / therapeutic use
  • Female
  • Humans
  • Immunophenotyping
  • Keratins / metabolism
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / drug therapy
  • Leishmaniasis, Visceral / immunology
  • Lymph Nodes / pathology
  • Recurrence
  • T-Lymphocytopenia, Idiopathic CD4-Positive / complications*
  • T-Lymphocytopenia, Idiopathic CD4-Positive / immunology

Substances

  • Antipruritics
  • liposomal amphotericin B
  • Allopurinol
  • Keratins
  • Amphotericin B