The purpose of the present investigation was to evaluate the holotopy, skeletotopy and sintopy of human heart, trachea and esophagus in the early fetal period. The quantitative evaluation of the topography of these organs was given as a result of study of 100 human fetuses aged 16-24 week with the modification of N.I. Pirogov method and using the multiplane histotopographical sections in the multidimensional coordinate system. The horizontal sections were selected, that could be proposed as the standard ones. he results of this investigation may be recommended for the improvement of the ultrasonographic and magnetic resonance tomographic diagnosis and fetal surgery development.