CD44 keeps tumor killers polarized

Thorsten R Mempel; Francesco Marangoni

doi:10.1016/j.immuni.2008.12.004

CD44 keeps tumor killers polarized

Immunity. 2008 Dec 19;29(6):843-5. doi: 10.1016/j.immuni.2008.12.004.

Authors

Thorsten R Mempel¹, Francesco Marangoni

Affiliation

¹ Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tmempel@mgh.harvard.edu

PMID: 19100697
DOI: 10.1016/j.immuni.2008.12.004

Abstract

In this issue of Immunity, Mrass et al. (2008) report that CD44 critically contributes to the stabilization of polarity in migrating cytotoxic T lymphocytes by anchoring cytoskeletal proteins to the cell membrane at their uropods.

Publication types

Comment

MeSH terms

Animals
Cell Membrane / immunology
Cell Membrane / metabolism*
Cell Movement
Cell Polarity / immunology
Cytoskeletal Proteins / immunology
Cytoskeletal Proteins / metabolism*
Cytoskeleton / immunology
Cytoskeleton / metabolism*
Hyaluronan Receptors / immunology
Hyaluronan Receptors / metabolism*
Mice
Neoplasms / immunology
Neoplasms / metabolism
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Cytotoxic / metabolism

Substances

Cytoskeletal Proteins
Hyaluronan Receptors