Abstract
A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 microM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Chromatography, High Pressure Liquid
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Euphorbia / chemistry*
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HL-60 Cells
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Humans
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Macrocyclic Compounds / chemistry*
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Macrocyclic Compounds / isolation & purification
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Macrocyclic Compounds / pharmacology*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Plant Extracts / analysis
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Plant Preparations / analysis
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Spectrophotometry, Ultraviolet
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X-Ray Diffraction
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Macrocyclic Compounds
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Plant Extracts
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Plant Preparations