The final paper of this special issue devoted to prevention and social justice calls for prevention practitioners and researchers to redirect their energy and resources to creating genuine social change. To begin, the contribution of the American Psychological Association ethical code to social justice-oriented prevention work is explored, and significant ethical issues that need to be further addressed by the current code are briefly outlined. Second, we discuss the implications of a social justice approach to prevention for training, practice and research. Finally, we invite readers to take the lead in putting a social justice prevention approach into practice.